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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: Br J Pharmacol. 2022 Dec 5;180(5):667–680. doi: 10.1111/bph.15903

Figure 5: C781 limits acute A. alternata-induced inflammatory cytokine production.

Figure 5:

Eleven different cytokines (A - K) were significantly increased in the BALF of A. alternata-treated animals with all but two (F: IL-4, H: IFNγ) significantly reduced by C781 co-treatment. Notably both IL-4 and IFNγ in Alt + C781-treated animals were not significantly different than either control. Altered cytokines are associated with eosinophil recruitment -- (A) Eotaxin, (B) IL-5 and (C) CCL6; neutrophil recruitment -- (D) GCP-2; (E) KC/GRO; TH2 cell responses -- (F) IL-4; (G) MDC; inflammation -- (H) IFNγ, (I) IL-10, and (J) IP-10; and/or tissue remodeling -- (K) TIMP-1. Three inflammatory cytokines (L: GM-CSF, M: IL-6, N: IL1α) were significantly altered by C781 alone treatment, however, this difference was not observed after Alt exposure. Cytokine data was from 5 animals in each group. * denotes significant difference between Alt and HBSS control; # denotes significant difference between Alt and Alt + C781; ^ denotes significant difference between Alt and C781 control.