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. 2023 Jun 15;17:1213732. doi: 10.3389/fncel.2023.1213732

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Copyright © 2023 Giustizieri, Petrillo, D’Amico, Torda, Quatrana, Vigevano, Specchio, Piemonte and Cherubini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RSL3 affects the excitatory/inhibitory balance. (A) Samples of outward (GABAergic) and inward (glutamatergic) synaptic currents evoked in layer IV principal cells by stimulation of afferent fibers at the reversal potential of glutamate (0 mV) and GABA (–70 mV), respectively, in the absence (black) and in the presence (red) of RSL3 (5 μM). Note the decrease in amplitude of the IPSC and the increase in amplitude of the EPSC in RSL3. (B) Each column represents the mean area underlying the evoked EPSC or IPSC in the absence (black) or in the presence (red) of RSL3. Bars are the SEM. (C) Each column represents the mean E/I ratio (± SEM) observed in control (n = 7/3 animals; black) or in RSL3 (n = 7/3 animals; red). *p < 0.05 (paired Student’s t-test).