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. 2023 Jun 15;17:1213732. doi: 10.3389/fncel.2023.1213732

FIGURE 6.

FIGURE 6

RSL3 reduces the probability of GABA release and enhances that of glutamate release. (A) Left: sample traces of IPSCs evoked in layer IV spiny neurons by two stimuli (50 ms apart) delivered to afferent GABAergic inputs (in the presence of CNQX), in the absence (black) or in the presence (red) of RSL3 (5 μM). Right: each column represents the mean ratio between the second and first IPSC in control conditions (black; n = 8/3) or in the presence of RSL3 (5 μM, red; n = 8/3). Bars are the SEM. Open circles represent individual values. *p < 0.05 (paired Student’s t-test). (B) Left: sample traces of EPSCs evoked in layer IV spiny neurons by two stimuli (50 ms apart) delivered to afferent glutamatergic inputs (in the presence of picrotoxin), in the absence (black) or in the presence (red) of RSL3 (5 μM). Right: each column represents the mean ratio between the second and first EPSC in control conditions (black; n = 9/3) or in the presence of RSL3 (red; n = 9/3). Bars are the SEM. Open circles represent individual values; *p < 0.05 (paired Student’s t-test).