FIGURE 8.

Vitamin E prevents or reduces the frequency of interictal bursts induced by increasing concentrations of RSL3. (A) Representative traces showing the beneficial effects of Vitamin E (30 μM) on bursting activity induced at –70 mV in layer IV spiny neurons by RSL3 concentrations of 5 and 10 μM. Note that Vitamin E prevents interictal discharges caused by 5 μM RSL3 (n = 6/4 animals) and significantly reduces those produced by 10 μM RSL3 (n = 6/4animals). Vitamin E alone (30 μM), did not modify the spontaneous firing of layer IV spiny neurons (see representative trace at the top). Firing or bursting activity marked by an asterisk is shown on the right on an expanded time scale. (B) Dose-response curves of burst’s frequency induced by increasing concentrations of RSL3 (continuous line) and by RSL3 plus Vitamin E (30 μM; dashed line). Bars are the SEM. *p < 0.05 (two way ANOVA test).