Figure 3.

Deconvolution of SAXS peaks correlates to ASO-lipid compartmentalization in the LNP core. Deconvolution of primary SAXS peaks of a representative LNP formulation using three Lorentz functions associated with disordered, H_II, and L_α phase signals. The center of Lorentz functions and its lower and upper bounds used in the fitting of the three phases are highlighted with violet, red, and blue stripes, respectively. See Materials and Methods section for detailed description of the fitting approach.