Skip to main content
. 2023 Jun 6;17(12):11454–11465. doi: 10.1021/acsnano.3c01186

Figure 5.

Figure 5

LNP structure determined by SAXS features relates to in vitro efficacy. (A) DLS-based LNP sizes do not show a significant correlation with relative TMEM106b mRNA expression that can be predictively used for hit identification. (B) Correlation between disordered/HII Lorentz function area ratios and relative TMEM106b mRNA expression across the library of 54 LNP formulations. See the Materials and Methods section for derivation of Lorentz function area. The data are colored based on the LNP size measured by DLS (inset legend). (C) A comparison between the bottom and top 15% of the ratio values and relative TMEM106b mRNA expression suggests an ordered LNP core character results in efficacious formulations.