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. 2023 May 11;9(6):1111–1118. doi: 10.1021/acscentsci.3c00177

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© 2023 The Authors. Published by American Chemical Society

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CB2 specifically binds several subtypes of B cell lymphoma. Flow cytometry binding assays with different lymphoma cell lines and healthy human PBMCs. Orange histograms show CB2 binding, gray histograms is secondary antibody control. Screened cells are SC-1 (follicular lymphoma), DoHH-2 (follicular lymphoma), SU-DHL-4 (diffuse large B cell lymphoma), Raji (Burkitt’s lymphoma), JeKo-1 (mantle cell lymphoma), and healthy human PBMCs. CB2 (24 μM) binding after 60 min was detected with anti-His-647 Ab (Rockland Inc., 1:500) targeting CB2’s C-terminal His-tag.