Table 2.
Odds ratios of CAN or DSPN by a 50% higher level of serum and urine collagen markers
| Model 1 | Model 2 | Model 3 | |
|---|---|---|---|
| Odds ratio of CAN | |||
| Serum PRO-C6 (ng/ml) | 2.44 (1.78;3.34) [< 0.001] | 2.41 (1.73;3.38) [< 0.001] | 1.66 (1.03;2.66) [0.035] |
| Serum C3M (ng/ml) | 1.78 (1.19;2.66) [0.004] | 1.73 (1.11;2.67) [0.012] | 1.30 (0.78;2.15) [0.312] |
| Urine PRO-C6 (ng/µmol) | 1.74 (1.06;2.88) [0.018] | 1.66 (0.96;2.89) [0.049] | 0.86 (0.48;1.54) [0.615] |
| Urine C3M (ng/µmol) | 0.56 (0.42;0.73) [< 0.001] | 0.57 (0.42;0.76) [< 0.001] | 0.85 (0.60;1.21) [0.380] |
| Odds ratio of DSPN | |||
| Serum PRO-C6 (ng/ml) | 1.70 (1.28;2.26) [< 0.001] | 1.60 (1.19;2.15) [0.001] | 1.20 (0.78;1.84) [0.404] |
| Serum C3M (ng/ml) | 1.29 (0.88;1.90) [0.192] | 1.16 (0.77;1.74) [0.475] | 0.94 (0.60;1.46) [0.768] |
| Urine PRO-C6 (ng/µmol) | 1.22 (0.76;1.04) [0.415] | 1.02 (0.62;1.70) [0.925] | 0.69 (0.39;1.21) [0.195] |
| Urine C3M (ng/µmol) | 0.81 (0.63;1.05) [0.108] | 0.85 (0.65;1.10) [0.223] | 1.17 (0.82;1.67) [0.373] |
Estimates of linear logistic regression models presented as odds ratios (95% confidence intervals, P-values) of CAN or DSPN as a function of a 50% increase in determinants: Model 1 adjusted for age and sex, Model 2 further adjusted for diabetes duration, HbA1c, BMI, smoking, systolic blood pressure, LDL cholesterol and beta blocker treatment (only for CAN), Model 3 additionally adjusted for eGFR. CAN: cardiovascular autonomic neuropathy; DSPN: distal symmetrical polyneuropathy; PRO-C6: Collagen type VI (COL6); C3M III: Collagen type (COL3)