Table 3.
% changes in CARTs by a 50% higher level of serum and urine collagen markers
| Model 1 | Model 2 | Model 3 | |
|---|---|---|---|
| E/I ratio | |||
| Serum PRO-C6 (ng/ml) | − 2.77 (− 3.83; − 1.72) [< 0.001] | − 2.34 (− 3.38; − 1.30) [< 0.001] | − 0,66 (− 2.23;0.93) [0.411] |
| Serum C3M (ng/ml) | − 1.70 (− 3.45;20.08) [0.063] | − 1.18 (− 2.87;0.55) [0.181] | − 0.08 (0.176;1.63) [0.929] |
| Urine PRO-C6 (ng/µmol) | − 2.05 (− 4.03; − 0.03) [0.048] | − 1.71 (− 3.63;0.230) [0.086] | 0.32 (− 1.73;2.42) [0.761] |
| Urine C3M (ng/µmol) | 2.42 (1.37;3.49) [< 0.001] | 1.97 (0.95;3.01) [0.002] | 0.82 (− 0.39;2.04) [0.187] |
| 30/15 ratio | |||
| Serum PRO-C6 (ng/ml) | 1.02 (0.04; 2.01) [0.043] | − 1.42 (− 2.42; − 0.41) [0.006] | − 0.71 (− 2.27;0.87) [0.378] |
| Serum C3M (ng/ml) | − 0.63 (− 2.21;0.98) [0.442] | − 0.35 (− 1.94;127) [0.670] | 0.25 (− 1.37;1.90) [0.760] |
| Urine PRO-C6 (ng/µmol) | − 0.40 (− 2.26;1.49) [0.675] | − 0.32 (− 2.18;1.58) [0.741] | 0.89 (− 1.16;2.99) [0.399] |
| Urine C3M (ng/µmol) | 0.81 (0.63;1.05) [0.108] | 0.86 (− 0.14;1.86) [0.093] | 0.17 (− 1.03;1.39) [0.781] |
| Valsalva ratio | |||
| Serum PRO-C6 (ng/ml) | − 5.32 (− 7.73; − 2.85) [< 0.001] | − 4.31 (− 6.82; − 1.74) [0.001] | 1.20 (0.78;1.84) [0.404] |
| Serum C3M (ng/ml) | − 0.46 (− 4.74;4.04) [0.843] | 1.43 (− 2.85;5.90) [0.518] | 2.74 (− 1.50;7.16) [0.209] |
| Urine PRO-C6 (ng/µmol) | − 6.49 (− 10.47; − 2.33) [0.003] | − 5.26 (− 9.27; − 1.08) [0.015] | − 2.17 (− 6.76;2.67) [0.373] |
| Urine C3M (ng/µmol) | 4.78 (2.07;7.55) [< 0.001] | 4.20 (1.53;6.95) [0.002] | 2.31 (− 0.74;5.44) [0.141] |
Estimates of linear regression models presented as % changes (95% confidence intervals, P-values) for CARTs as a function of a 50% increase in determinants: Model 1 adjusted for age and sex, Model 2 further adjusted for diabetes duration, HbA1c, BMI, smoking, systolic blood pressure, LDL cholesterol and beta blocker treatment (only for CAN), Model 3 additionally adjusted for eGFR. CARTs: cardiovascular autonomic reflex tests; PRO-C6: Collagen type VI (COL6); C3M III: Collagen type III (COL3)