Fig. 11.

Ri. treatment reversed colon barrier impairment in CRS mice. A, B H&E staining of the mice colons (scale bar 50 μm) along with the histological score analysis. C, D IF images C and MFI analysis D of Occludin; scale bar 20 μm. E mRNA expression of ISC markers. Data were displayed as mean ± SEM. Significant differences were determined via two-way ANOVA and Tukey’s multiple comparison procedure. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001, ^****p < 0.0001 vs. the CTR + PBS group; ^&p < 0.05, ^&&&p < 0.001, ^&&&&p < 0.0001 vs. the CTR + Ri group; ^#p < 0.05, ^##p < 0.01 vs. the CRS + PBS group