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. 2023 Jun 30;11:145. doi: 10.1186/s40168-023-01589-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Correlations between adolescent depression scale scores and Trp-Kyn pathway metabolites. A Correlations between RCADS-25 scores and metabolite levels in serum. Correlations between RCADS-25 and 5-HT and Quin levels in serum were shown as Pearson’s r values. Correlations between RCADS-25 scores and DA, Trp, Kyn, and Kyna levels in serum were shown as Spearman’s r values. B Correlations between RCADS-25 scores and metabolite levels in urine. Correlation between RCADS-25 scores and Trp levels in urine is shown as Pearson’s r value. Correlations between RCADS-25 scores and 5-HT, Kyn, Kyna, and Quin levels in urine were shown as Spearman’s r values