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Potential roles for DNA methylation in the dysfunction of oligodendrocytes and myelin in neurodegenerative diseases. Panels illustrate different lines of evidence that implicate DNA methylation changes affecting OLGs/OLG-related genes and their relevance to neurodegeneration. BIN1—Bridging interactor 1, MOBP—Myelin associated oligodendrocyte protein, OPC—Oligodendrocyte precursor cell, OLG—Oligodendrocyte, ROS—Reactive oxygen species. Figure created with BioRender
