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Epigenetic modification and acquired resistance to ICI therapy. A: Epigenetic silencing of gene of T helper 1-type chemokines CXCL9 and CXCL10 results in CD8+ T cell homing and infiltration to the TME. B: Acquisition of memory potential was limited after reinvigoration of exhausted T cells with PD-L1 blockade. Reinvigorated exhausted T cells fail to become memory T cells after antigens clearance and they will become depleted again, even if neoantigens are exposed again
