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. 2023 Jun 30;25:111. doi: 10.1186/s13075-023-03089-5

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Whole blood gene signature in patients exposed to MMF. A Volcano plot to show differentially expressed genes between patients exposed to MMF or not. The y-axis shows -log10 adjusted p value and x-axis shows log2 fold change. Genes in red are differentially upregulated or downregulated with log2 fold change > 0.5 and adjusted p value < 0.05. B Gene set enrichment analysis of the 2607 differentially expressed genes. The x-axis shows the number of genes contributing to the term and the colour of the bar represents the p value. C Box plots of the 3 genes most significantly upregulated or downregulated according to MMF exposure. Horizontal bar shows median. Comparisons with Kruskal–Wallis test with Dunn’s correction. *p < 0.05, ****p < 0.0001