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. 2023 Jun 30;25:111. doi: 10.1186/s13075-023-03089-5

Table 3.

Ordered logistic regression models of the association between MMF exposure and quartiles of peripheral blood immune cell frequency

Cell type (quartiles) Unadjusted Model 1a Model 2b
OR 95% CI p OR 95% CI p OR 95% CI p
Resting macrophages 0.354 0.176, 0.771 0.004 0.386 0.178, 0.840 0.016 0.329 0.177, 0.872 0.022
Naïve CD4 + T cells 0.390 0.195, 0.776 0.007 0.398 0.184, 0.859 0.019 0.369 0.167, 0.816 0.014
Regulatory T cells 0.363 0.181, 0.728 0.004 0.227 0.099, 0.521  < 0.001 0.216 0.092, 0.508  < 0.001
Activated CD4 + memory T cells 1.952 0.984, 3.869 0.055 2.174 1.014, 1.659 0.046 2.447 1.120, 5.346  < 0.001
Monocytes 0.528 0.266, 1.045 0.067 0.527 0.244, 1.139 0.103 0.579 0.262, 1.279 0.176

aModel 1: adjusted for age, gender, ethnicity, and disease duration

bModel 2: as for model 1 plus presence of renal disease (BILAG A/B) and corticosteroid use (Y/N)