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. 2023 Jun 29;22:162. doi: 10.1186/s12933-023-01899-0

Table 1.

[5] Key pharmacodynamic- and kinetic parameters of steroidal MRA and finerenone. MR: mineralocorticoid receptor; MRA: MR-antagonist; CNS: central nervous system; BP: blood pressure

Steroidal MRA Non-steroidal MRA
Spironolactone Eplerenone Finerenone
Structural properties Flat (steroidal) Flat (steroidal) Bulky (non-steroidal)
MR-Affinity +++ + +++
MR-Selectivity + ++ +++
Sex-hormone-related side effects ++ (+) -
CNS penetration + + -
Plasma half-life > 20 h 4-6 h 2-3 h
Effect on BP +++ ++ +