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. 2023 Jun 16;14:1204363. doi: 10.3389/fimmu.2023.1204363

Figure 3.

Figure 3

The main ideas to reinvigorate exhausted CD8+ T cells. There are four main ideas to reinvigorate exhausted CD8+ T cells in tumor microenvironment. (A) Tpex expansion and further expansion of terminally exhausted T cells. (B) Promotion of Tpex differentiation into terminally exhausted subsets with better effector function. (C) Self-renewal of terminally exhausted T cells. (D) Promotion of Tpex differentiation into other effector subsets.