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. 2023 Jan 30;18(6):736–744. doi: 10.1177/17474930231153313

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© The Author(s) 2023

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Twelve-month mean CVR changes in candesartan (green) versus placebo (blue) for whole brain (A), frontal (B), parietal (C), temporal (D) lobes, and hippocampus (E)—results from CEDAR trial only. p-values correspond to between-group differences (visit × group), calculated from mixed-model repeated measures of CVR over the study period. Error bars are standard errors. Change in ETCO₂ during CO₂ exposure and sitting systolic blood pressure were included as covariates in all repeated measure models.