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. 2023 Jan 30;18(6):736–744. doi: 10.1177/17474930231153313

Figure 5.

Figure 5.

Twelve-month mean CVR changes in candesartan (green) versus lisinopril (red) for whole brain (A), frontal (B), parietal (C), temporal (D) lobes, and hippocampus (E)—results from CALIBREX trial only. p-values correspond to between-group differences (visit × group), calculated from mixed-model repeated measures of CVR over the study period. Error bars are standard errors. Change in ETCO2 during CO2 exposure, sitting systolic blood pressure, and pre-study antihypertensive medication were included as covariates in all repeated measure models.