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. 2023 Jun 28;24(1):2226418. doi: 10.1080/15384047.2023.2226418

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Data from COAD and READ showed that the expression of M2 macrophage increases with the increasement of Treg cells. In Treg cells and M2 macrophage cells, PD-1 gene expression increases with the increasement of Tim-3. — Correlations between Tregs and M2 macrophages in colorectal cancer. (a) A positive correlation between Treg coding gene FOXP3 with M2 macrophage. M2 macrophage coding genes CD163 and MRC1 presented high positive correlations with tumor infiltrated Tregs in both COAD (n=458) and READ (n=166). (b) Cytokines IL-10 coding gene IL-10 and TGF-β coding gene TGF-β1 demonstrated a high positive correlation neither in Tregs or M2 macrophages in CRC patients’ cohorts (COAD and READ).