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. 2023 Jun 28;24(1):2226418. doi: 10.1080/15384047.2023.2226418

Figure 5.

The number of Treg cells and M2 macrophages were decreased when treated with Sttatic with anti-PD-1 treatment, while the number of CD8+ T cells increased. The decreased frequency of Treg cells after combination was associated with increased proliferation of CD8+ T cells and CD4+ T cells and higher ratios of CD8+ T cells to CD4+ T cells.

Stattic enhanced the immune response of PD-1 mAb therapy in the CT-26 mouse model. (a) Contour images and quantification of tumor infiltrated CD8+T cells in the CRC mouse model. (b) Tumor-associated CD4+ T cells were presented and quantified by flow analysis. (c) Analysis of the ratio of CD8+T cells to CD4+T cells in the tumors after combinatorial Stattic and PD-1 mAb therapy. (d) Percentages of CD4+Foxp3+ cells from CT26 tumors upon combinatorial Stattic and PD-1 mAb therapy compared to control groups. (e) CD11b+F4/80+ cells in the tumor after combinatorial Stattic and PD-1 mAb therapy. (f) Quantification of M2 macrophages marker CD206 positive cells from tumors after different therapies. Significance is indicated as * p < .05 or ** p < .01.