Vascular access-related complications for percutaneous mechanical support devices. The illustration shows different vascular access-related complications including access site hematoma, limb ischemia, thrombosis, pseudoaneurysm, aneurysm and contained rupture with callout data to risk factors, frequency, and associated outcomes. The above panel illustrates percutaneous mechanical support device in the right axillary artery and the lower panel illustrates the device in the right common femoral artery. All vascular and bleeding complications listed can occur using transfemoral, transaxillary, or transcaval (not shown in Figure) access. The Figure is meant to highlight the most common complications associated with large bore access in all types of MCS.