Figure 2.

Neonatal disease and ferroptosis. Newborns are easily exposed to oxidative stress environments such as hypoxia, hyperoxia, infection, inflammation, acidosis, and blood transfusion after birth, and their antioxidant capacity and iron metabolism capacity are poor, which will lead to increased ROS and free iron, and then cause ferroptosis through lipid peroxidation. A variety of neonatal diseases may be caused by ferroptosis, such as hypoxic-ischemic encephalopathy, bronchopulmonary dysplasia, necrotizing enterocolitis, and retinopathy of prematurity.

Note: Adapted from Du X, Dong R, Wu Y, Ni B. Physiological effects of ferroptosis on organ fibrosis. Oxid Med Cell Longev. 2022;2022:5295434.⁶²