Table 3.

Progression free survival hazard ratios (HR) for each stage and subgroup by metformin exposure.

Stratification	HR (CI)	p-value
All	0.883 (0.64-1.22)	0.447
I	1.368 (0.42-4.5)	0.603
II	0.682 (0.39-1.19)	0.181
I+II	0.757 (0.46-1.24)	0.269
III	0.785 (0.47-1.30)	0.349
III+IMT	0.881 (0.49-1.60)	0.676
IV	1.866 (0.78-4.44)	0.159
IV+IMT	1.519 (0.60, 3.87)	0.381
BRAF+ (all)	1.385 (0.68-2.82)	0.37
MBM (all)	1.315 (0.63-2.76)	0.468
BMI >30 (all)	1.058 (0.67-1.68)	0.81
BMI <30 (all)	0.76 (0.48-1.21)	0.249