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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1970 May;29(3):220–231. doi: 10.1136/ard.29.3.220

Failure of cytotoxic drugs to suppress immune responses of patients with rheumatoid arthritis.

E J Denman, A M Denman, B M Greenwood, D Gall, R B Heath
PMCID: PMC1031255  PMID: 4194200

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANSELL B. M., BYWATERS E. G. Prognosis in Still's disease. Bull Rheum Dis. 1959 May;9(9):189–192. [PubMed] [Google Scholar]
  2. BOREL Y., SCHWARTZ R. INHIBITION OF IMMEDIATE AND DELAYED HYPERSENSITIVITY IN THE RABBIT BY 6-MERCAPTOPURINE. J Immunol. 1964 May;92:754–761. [PubMed] [Google Scholar]
  3. BUTLER W. T., COONS A. H. STUDIES ON ANTIBODY PRODUCTION. XII. INHIBITION OF PRIMING BY DRUGS. J Exp Med. 1964 Dec 1;120:1051–1060. doi: 10.1084/jem.120.6.1051. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bach J. F., Dardenne M., Fournier C. In vitro evaluation of immunosuppressive drugs. Nature. 1969 Jun 7;222(5197):998–999. doi: 10.1038/222998a0. [DOI] [PubMed] [Google Scholar]
  5. Berenbaum M. C. Immunosuppressive agents: the design of selective therapeutic schedules. Antibiot Chemother. 1969;15:155–176. doi: 10.1159/000386779. [DOI] [PubMed] [Google Scholar]
  6. Chanmougan D., Schwartz R. S. Enhancement of antibody synthesis by 6-mercaptopurine. J Exp Med. 1966 Sep 1;124(3):363–378. doi: 10.1084/jem.124.3.363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Corley C. C., Jr, Lessner H. E., Larsen W. E. Azathioprine therapy of "autoimmune" diseases. Am J Med. 1966 Sep;41(3):404–412. doi: 10.1016/0002-9343(66)90086-6. [DOI] [PubMed] [Google Scholar]
  8. DIXON F. J., McCONAHEY P. J. Enhancement of antibody formation by whole body x-radiation. J Exp Med. 1963 May 1;117:833–848. doi: 10.1084/jem.117.5.833. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Davies A. J. The thymus and the cellular basis of immunity. Transplant Rev. 1969;1:43–91. doi: 10.1111/j.1600-065x.1969.tb00136.x. [DOI] [PubMed] [Google Scholar]
  10. Denman A. M., Denman E. J., Embling P. H. Changes in the life-span of circulating small lymphocytes in mice after treatment with anti-lymphocyte globulin. Lancet. 1968 Feb 17;1(7538):321–325. doi: 10.1016/s0140-6736(68)90791-5. [DOI] [PubMed] [Google Scholar]
  11. Denman E. J., Denman A. M. The lymphocyte transformation test and gold hypersensitivity. Ann Rheum Dis. 1968 Nov;27(6):582–589. doi: 10.1136/ard.27.6.582. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. FAHEY J. L., MCKELVEY E. M. QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES. J Immunol. 1965 Jan;94:84–90. [PubMed] [Google Scholar]
  13. Fosdick W. M., Parsons J. L., Hill D. F. Long-term cyclophosphamide therapy in rheumatoid arthritis. Arthritis Rheum. 1968 Apr;11(2):151–161. doi: 10.1002/art.1780110205. [DOI] [PubMed] [Google Scholar]
  14. Gabrielsen A. E., Good R. A. Chemical suppression of adaptive immunity. Adv Immunol. 1967;6:91–229. doi: 10.1016/s0065-2776(08)60522-2. [DOI] [PubMed] [Google Scholar]
  15. HEATH R. B., TYRRELL D. A., PETO S. Serological studies with Sendai virus. Br J Exp Pathol. 1962 Aug;43:444–450. [PMC free article] [PubMed] [Google Scholar]
  16. HOYER L. W., GOOD R. A., CONDIE R. M. Experimental allergic encephalomyelitis: the effect of 6-mercaptopurine. J Exp Med. 1962 Sep 1;116:311–327. doi: 10.1084/jem.116.3.311. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Hurd E. R., Ziff M. Studies on the anti-inflammatory action of 6-mercaptopurine. J Exp Med. 1968 Oct 1;128(4):785–800. doi: 10.1084/jem.128.4.785. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Kahn M. F., Bedoiseau M., de Sèze S. Immunosuppressive drugs in the management of malignant and severe rheumatoid arthritis. Proc R Soc Med. 1967 Feb;60(2):130–133. [PMC free article] [PubMed] [Google Scholar]
  19. Leventhal B. G., Waldorf D. S., Talal N. Impaired Lymphocyte Transformation and Delayed Hypersensitivity in Sjögren's Syndrome. J Clin Invest. 1967 Aug;46(8):1338–1345. doi: 10.1172/JCI105626. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Lorenzen I., Videbaek A. Treatment of collagen diseases with cytostatics. Lancet. 1965 Sep 18;2(7412):558–561. doi: 10.1016/s0140-6736(65)90866-4. [DOI] [PubMed] [Google Scholar]
  21. Lubaroff D. M., Waksman B. H. Bone marrow as a source of cells in reactions of cellular hypersensitivity. I. Passive transfer of tuberculin sensitivity in syngeneic systems. J Exp Med. 1968 Dec 1;128(6):1425–1435. doi: 10.1084/jem.128.6.1425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Mackaness G. B. The influence of immunologically committed lymphoid cells on macrophage activity in vivo. J Exp Med. 1969 May 1;129(5):973–992. doi: 10.1084/jem.129.5.973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Mason M., Currey H. L., Barnes C. G., Dunne J. F., Hazleman B. L., Strickland I. D. Azathioprine in rheumatoid arthritis. Br Med J. 1969 Feb 15;1(5641):420–422. doi: 10.1136/bmj.1.5641.420. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Miller J. F., Mitchell G. F. Thymus and antigen-reactive cells. Transplant Rev. 1969;1:3–42. doi: 10.1111/j.1600-065x.1969.tb00135.x. [DOI] [PubMed] [Google Scholar]
  25. Miller J. J., 3rd, Cole L. J. Resistance of long-lived lymphocytes and plasma cells in rat lymph nodes to treatment with prednisone, cyclophosphamide, 6-mercaptopurine, and actinomycin D. J Exp Med. 1967 Jul 1;126(1):109–125. doi: 10.1084/jem.126.1.109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Moens C., Brocteur J. Treatment of rheumatoid arthritis with immunosuppressive drugs. I. Clinical study. Acta Rheumatol Scand. 1965;11(3):212–220. doi: 10.3109/rhe1.1965.11.issue-1-4.25. [DOI] [PubMed] [Google Scholar]
  27. Möller G. Induction of DNA synthesis in normal human lymphocyte cultures by antigen-antibody complexes. Clin Exp Immunol. 1969 Jan;4(1):65–82. [PMC free article] [PubMed] [Google Scholar]
  28. O'Brien W. Cyclophosphamide vs. conservative treatment of rheumatoid arthritis. Arthritis Rheum. 1968 Oct;11(5):698–699. doi: 10.1002/art.1780110516. [DOI] [PubMed] [Google Scholar]
  29. PAGE A. R., CONDIE R. M., GOOD R. A. SUPPRESSION OF PLASMA CELL HEPATITIS WITH 6-MERCAPTOPURINE. Am J Med. 1964 Feb;36:200–213. doi: 10.1016/0002-9343(64)90083-x. [DOI] [PubMed] [Google Scholar]
  30. PLOTZ C. M., SINGER J. M. The latex fixation test. I. Application to the serologic diagnosis of rheumatoid arthritis. Am J Med. 1956 Dec;21(6):888–892. [PubMed] [Google Scholar]
  31. Renier J. C., Deshayes P., Besson J., Barazer C., Delahaye D., Bregeon C. Traitement de la polyarthrite rhumatoïde par le chlorambucil. A propos de 48 observations. Presse Med. 1967 Nov 25;75(50):2527–2530. [PubMed] [Google Scholar]
  32. Rhodes K., Scott A., Markham R. L., Monk-Jones M. E. Immunological sex differences. A study of patients with rheumatoid arthritis, their relatives, and controls. Ann Rheum Dis. 1969 Mar;28(2):104–120. doi: 10.1136/ard.28.2.104. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Salomon J. C., Benveniste J. The immune response in NZBxNZW F1 hybrid mice. Clin Exp Immunol. 1969 Feb;4(2):213–225. [PMC free article] [PubMed] [Google Scholar]
  34. Simons M. J., Fitzgerald M. G. Apparent dissociation of antigen responsiveness and antibody production by human small lymphocytes in culture. Clin Exp Immunol. 1969 Jan;4(1):55–63. [PMC free article] [PubMed] [Google Scholar]
  35. Smith M. E., Ansell B. M., Bywaters E. G. Mortality and prognosis related to the amyloidosis of Still's disease. Ann Rheum Dis. 1968 Mar;27(2):137–145. doi: 10.1136/ard.27.2.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Spector W. G., Willoughby D. A. The origin of mononuclear cells in chronic inflammation and tuberculin reactions in the rat. J Pathol Bacteriol. 1968 Oct;96(2):389–399. doi: 10.1002/path.1700960217. [DOI] [PubMed] [Google Scholar]
  37. Swanson M. A., Schwartz R. S. Immunosuppressive therapy. The relation between clinical response and immunologic competence. N Engl J Med. 1967 Jul 27;277(4):163–170. doi: 10.1056/NEJM196707272770401. [DOI] [PubMed] [Google Scholar]
  38. Tennenbaum J. I., Pierre R. L., Cerilli G. J. Evaluation of immunosuppressive therapy and clinical course in renal transplants by in vitro lymphocyte transformation. Transplantation. 1968 Dec;6(9):986–990. doi: 10.1097/00007890-196812000-00004. [DOI] [PubMed] [Google Scholar]
  39. Vischer T. L. Lymphocyte cultures in drug hypersensitivity. Lancet. 1966 Aug 27;2(7461):467–469. doi: 10.1016/s0140-6736(66)92773-5. [DOI] [PubMed] [Google Scholar]

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