Figure 4 |. Long-range features of inosines observed with nanopore sequencing.

Aligned reads displaying a type II hyperediting, b coordinated editing, and c and d disruption of splicing in the presence of editing.In a and c, the top three coverage tracks are Illumina CTRL KD samples and the bottom coverage track and reads are displaying the nanopore CTRL KD reads. In b and d, the dataset on top displays the control nanopore reads and the bottom panel displays the ADAR knockdown reads. In b, orange marks correspond to A->G mismatches and in a, c, and d, positions marked with blue mismatches are T->C mismatches (A->G on the negative strand).