Table 3. The ten GO terms in which UHP isoforms are most over-represented.

Enrichment was tested using the hypergeometric test, where we draw UHP isoforms or other isoforms a number of times that equals the number of isoforms that are annotated to the GO term (Methods). Bonferroni multiple testing correction was applied (adjusted p-value column). Coverage refers to the proportion of isoforms annotated to the term that contain a UHP exon.

GO Term	Coverage	p.value	adj.p
JUN kinase activity (GO:0004705)	0.62	2.04×10−54	2.89×10−51
MAP kinase activity (GO:0004707)	0.49	2.22×10−54	3.13×10−51
MAP kinase kinase activity (GO:0004708)	0.59	7.68×10−50	1.08×10−46
response to light stimulus (GO:0009416)	0.60	7.90×10−44	1.11×10−40
actin binding (GO:0003779)	0.19	2.78×10−35	3.91×10−32
Fc-epsilon receptor signaling pathway (GO:0038095)	0.51	2.66×10−33	3.74×10−30
GPI-anchor transamidase complex (GO:0042765)	0.65	6.37×10−31	8.95×10−28
cytoskeleton organization (GO:0007010)	0.32	7.16×10−31	1.01×10−27
cytoskeletal protein binding (GO:0008092)	0.31	1.30×10−30	1.82×10−27
cellular senescence (GO:0090398)	0.44	1.02×10−29	1.43×10−26