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[Preprint]. 2023 Jun 16:2023.06.15.545195. [Version 1] doi: 10.1101/2023.06.15.545195

Figure 1.

Figure 1.

Characteristics of petite C. glabrata isolates. All petite isolates included in this study were fluconazole resistant (A) and did not carry PDR1 gain-of-function mutations, as confirmed by PDR1 sequencing. Petite isolates have a higher basal level of PDR1 and efflux pumps under its control (CDR1, CDR2, and SNQ2) once measured by real-time PCR (3 biological replicates, ***<0.01, ****<0.001, two-tailed t-test) (B). Petites had a lower ATP level (5 biological replicates, ****<0.001, two-tailed t-test) (C) and mitochondrial membrane potential (3 biological replicates, ***<0.01 and **=0.01, two-tailed t-test) (D) than their respiratory proficient counterparts. ATP: Adenosine triphosphate.