Figure 1: Genomic loci associated with the nine biological age gaps.

Organ-specific biological age gap (BAG) was derived from a large cohort of 30,108 to 111,543 European ancestry participants from the UK Biobank cohort. The nine organ systems include the brain (N=30,108), cardiovascular (N=111,543), eye (N=36,004), hepatic (N=111,543), immune (N=111,543), metabolic (N=111,543), musculoskeletal (N=111,543), pulmonary (N=111,543), and renal (N=111,543) BAGs. 393 genomic loci-BAG pairs were identified using a genome-wide P-value threshold [–log₁₀(P-value) > 7.30]. For visualization purposes, we denoted the genomic loci using their top lead SNPs that are not associated with any clinical traits in the EMBL-EBI GWAS Catalog. The anatomical illustration of the human body was created using BioRender.com. All analyses used the Genome Reference Consortium Human Build 37 (GRCh37). We present representative features employed in the calculation of each organ organ’s BAG. BMI: body mass index; IDP: imaging-derived phenotype; GM: gray matter; WM: white matter; FC: functional connectivity; OCT: optical coherence tomography; FVC: forced vital capacity; FEV: forced expiratory volume; PEF: peak expiratory flow.