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[Preprint]. 2023 Jun 21:2023.06.12.23291054. [Version 2] doi: 10.1101/2023.06.12.23291054

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Figure 7. — Lipid network module levels: longitudinal association results of lipid network modules with longitudinal change rates of A/T/N biomarkers. (A) The table showed longitudinal association results between lipid network modules and longitudinal change rates of A/T/N biomarkers. Asterisks indicate significant associations after FDR correction. Red colors indicate that higher ME values of the red-colored module were associated with worse progression of AD biomarkers, and blue colors indicate that lower ME values of the blue-colored module were significantly associated with worse progression of AD biomarkers. T statistic values were derived from linear mixed effect analysis and positive T statistic values indicate that higher ME values are associated with worse progression of AD biomarkers. (B) A Sankey diagram was used to visualize clustering of lipid species in the lipid network modules identified as significantly associated with cross-sectional or longitudinal changes of A/T/N biomarkers.