Table 2.

Blood RNA biomarker and CRP performance metrics for discrimination of sputum culture status.

Signature	AUROC	Sensitivity	Specificity	PPV	NPV	Triage positive	NNT(+)	NNT(−)	p
Suliman4	0.8 (0.75 – 0.86)	0.83 (0.74 – 0.9)	0.59 (0.55 – 0.63)	0.23 (0.19 – 0.28)	0.96 (0.93 – 0.97)	0.47 (0.43 – 0.51)	4.3 (3.5 – 5.3)	23.9 (14.8 – 39.2)	0.320
Risk6	0.79 (0.74 – 0.85)	0.91 (0.83 – 0.95)	0.39 (0.35 – 0.43)	0.18 (0.15 – 0.22)	0.97 (0.94 – 0.98)	0.65 (0.61 – 0.68)	5.4 (4.5 – 6.6)	29.8 (15.4 – 58.4)	0.575
Sweeney3	0.79 (0.73 – 0.85)	0.92 (0.85 – 0.96)	0.28 (0.25 – 0.32)	0.16 (0.13 – 0.2)	0.96 (0.92 – 0.98)	0.74 (0.71 – 0.77)	6.1 (5 – 7.5)	24.9 (12.4 – 51)	0.608
Gliddon3	0.79 (0.73 – 0.84)	0.89 (0.81 – 0.94)	0.31 (0.28 – 0.35)	0.16 (0.13 – 0.2)	0.95 (0.91 – 0.97)	0.71 (0.68 – 0.75)	6.1 (5 – 7.5)	19.4 (10.8 – 35.4)	0.608
CRP	0.78 (0.72 – 0.83)	0.85 (0.77 – 0.91)	0.48 (0.44 – 0.52)	0.2 (0.16 – 0.24)	0.96 (0.93 – 0.97)	0.56 (0.53 – 0.6)	5 (4.1 – 6.2)	22.7 (13.5 – 38.6)	NA
BATF2	0.75 (0.69 – 0.8)	0.82 (0.73 – 0.89)	0.53 (0.49 – 0.57)	0.21 (0.17 – 0.25)	0.95 (0.92 – 0.97)	0.52 (0.48 – 0.56)	4.8 (3.9 – 5.9)	20.4 (12.8 – 32.9)	0.405
Roe3	0.74 (0.68 – 0.8)	0.73 (0.63 – 0.81)	0.61 (0.57 – 0.65)	0.22 (0.18 – 0.27)	0.94 (0.91 – 0.96)	0.44 (0.4 – 0.48)	4.6 (3.7 – 5.7)	15.8 (10.8 – 23.4)	0.320
Zak11	0.73 (0.68 – 0.79)	0.56 (0.46 – 0.66)	0.77 (0.73 – 0.8)	0.27 (0.21 – 0.34)	0.92 (0.89 – 0.94)	0.28 (0.24 – 0.31)	3.7 (3 – 4.8)	12.6 (9.3 – 17)	0.320
W4SS	0.63 (0.58 – 0.68)	0.79 (0.69 – 0.86)	0.47 (0.43 – 0.51)	0.18 (0.15 – 0.23)	0.94 (0.9 – 0.96)	0.56 (0.53 – 0.6)	5.4 (4.4 – 6.8)	15.5 (10.2 – 24)	0.000

P values indicate pairwise comparisons to CRP, with multiple testing correction (n = 676 participants).