Table 3.

Blood RNA biomarker and CRP performance metrics for discrimination of TB status, stratified by selected subgroups.

Signature	W4SS-positive	W4SS-negative	p
BATF2	0.78 (0.72 – 0.84)	0.59 (0.43 – 0.74)	0.029
CRP	0.81 (0.76 – 0.87)	0.56 (0.42 – 0.7)	0.003
Gliddon3	0.83 (0.77 – 0.89)	0.58 (0.44 – 0.72)	0.003
Risk6	0.83 (0.78 – 0.89)	0.59 (0.46 – 0.72)	0.003
Roe3	0.77 (0.71 – 0.83)	0.57 (0.41 – 0.74)	0.029
Suliman4	0.84 (0.79 – 0.89)	0.6 (0.46 – 0.74)	0.003
Sweeney3	0.84 (0.79 – 0.9)	0.56 (0.42 – 0.7)	0.002
Zak11	0.75 (0.68 – 0.81)	0.65 (0.51 – 0.78)	0.193
Signature	CD4 <200 cells	CD4 >=200 cells	p
BATF2	0.76 (0.68 – 0.84)	0.7 (0.62 – 0.79)	0.482
CRP	0.84 (0.77 – 0.91)	0.7 (0.61 – 0.78)	0.112
Gliddon3	0.83 (0.75 – 0.9)	0.72 (0.63 – 0.81)	0.188
Risk6	0.83 (0.75 – 0.9)	0.73 (0.65 – 0.82)	0.188
Roe3	0.75 (0.66 – 0.83)	0.7 (0.61 – 0.79)	0.512
Suliman4	0.84 (0.76 – 0.92)	0.75 (0.67 – 0.83)	0.188
Sweeney3	0.84 (0.76 – 0.91)	0.73 (0.65 – 0.82)	0.188
Zak11	0.71 (0.62 – 0.8)	0.74 (0.65 – 0.82)	0.667
Signature	Culture-positive TB	Culture-negative TB	p
BATF2	0.75 (0.7 – 0.81)	0.69 (0.61 – 0.77)	0.447
CRP	0.79 (0.73 – 0.85)	0.79 (0.72 – 0.86)	0.978
Gliddon3	0.8 (0.74 – 0.86)	0.76 (0.68 – 0.84)	0.549
Risk6	0.8 (0.75 – 0.86)	0.75 (0.67 – 0.83)	0.447
Roe3	0.75 (0.69 – 0.81)	0.69 (0.61 – 0.77)	0.447
Suliman4	0.82 (0.76 – 0.87)	0.79 (0.72 – 0.86)	0.689
Sweeney3	0.8 (0.74 – 0.85)	0.7 (0.61 – 0.78)	0.361
Zak11	0.74 (0.69 – 0.8)	0.67 (0.6 – 0.75)	0.447

Accuracy shown for primary outcome of sputum culture status as area under the receiver operating characteristic curve with 95% confidence intervals. Reference standard for W4SS and CD4 strata is sputum culture, as per primary reference standard. Reference standard for the sputum culture strata is based on TB diagnosis or treatment recorded within six months of enrolment. P values indicate comparisons between strata for each signature.