Table 5.
Gene expression profiles in bone from MS2-treated wild-type control and Pkd1/TAZOc-cKO mice.
| Gene | Wild-type (Vehicle) | Wild-type (MS2) | Pkd1/TAZOc-cKO (Vehicle) | Pkd1/TAZOc-cKO (MS2) |
|---|---|---|---|---|
|
| ||||
| Pkd1 | 1.00±0.13 | 0.94±0.15 | 1.00±0.37 | 1.03±0.28 |
| TAZ | 1.00±0.32 | 1.01±0.32 | 1.00±0.40 | 0.82±0.19 |
| Runx2-II | 1.00±0.19 | 1.79±0.52** | 1.00±0.32 | 1.03±0.28 |
| Osteocalcin | 1.00±0.24 | 1.68±0.24*** | 1.00±0.57 | 0.86±0.61 |
| ALP | 1.00±0.14 | 1.56±0.23*** | 1.00±0.52 | 1.09±0.55 |
| Dmp1 | 1.00±0.18 | 1.45±0.17*** | 1.00±0.33 | 1.02±0.48 |
| OPG | 1.00±0.38 | 1.10±0.37 | 1.00±0.30 | 1.18±0.33 |
| RankL | 1.00±0.30 | 0.57±0.15* | 1.00±0.50 | 0.99±0.33 |
| Trap | 1.00±0.26 | 0.56±0.10* | 1.00±0.58 | 0.93±0.28 |
| PPARγ2 | 1.00±0.43 | 0.59±0.11* | 1.00±0.47 | 1.06±0.18 |
| aP2 | 1.00±0.22 | 0.60±0.26* | 1.00±0.22 | 1.07±0.12 |
| Lpl | 1.00±0.28 | 0.63±0.12* | 1.00±0.40 | 0.95±0.39 |
| Wnt1 | 1.00±0.30 | 3.02±0.98*** | 1.00±0.60 | 0.97±0.40 |
| Wnt10b | 1.00±0.15 | 1.52±0.25*** | 1.00±0.40 | 1.12±0.21 |
| FzD2 | 1.00±0.26 | 3.36±1.56*** | 1.00±0.30 | 0.95±0.18 |
| c-Fos | 1.00±0.20 | 1.47±0.34* | 1.00±0.22 | 1.00±0.27 |
| c-Jun | 1.00±0.23 | 1.74±0.24*** | 1.00±0.29 | 0.84±0.20 |
| Axin-2 | 1.00±0.22 | 2.57±1.02** | 1.00±0.16 | 0.92±0.17 |
| PTGS2 | 1.00±0.35 | 2.25±0.78** | 1.00±0.26 | 0.90±0.22 |
| eNOS | 1.00±0.45 | 3.09±0.68*** | 1.00±0.13 | 1.03±0.22 |
Data are mean ± S.D. from 6 tibias of wild-type control and Pkd1/TAZOc-cKO mice and expressed as the fold changes relative to the housekeeping gene eEF1a1 subsequently normalized to control or Pkd1/TAZOc-cKO no load tibias.
*, **, *** indicates significant difference from wild-type control at P<0.05, P<0.01, P<0.001.