Table 2:
Odds Ratios (OR) of pathological complete response (pCR) by BMI categories and adjusted variables
| # of pts | pCR | OR (95% CI) | P | OR (95% CI) | P | |
|---|---|---|---|---|---|---|
| (N) | N (%) | Unadjusted | Adjusted* | |||
| BMI | ||||||
| Normal / Underweight | 348 | 114 (32.8) | 1 (Ref.) | 1 (Ref.) | ||
| Overweight | 309 | 97 (31.4) | 0.94 (0.68–1.30) | 0.71 | 0.97 (0.64– 1.47) | 0.88 |
| Obese | 320 | 104 (32.5) | 0.99 (0.71–1.37) | 0.94 | 1.05 (0.68– 1.63) | 0.83 |
| BMI (continuous, per additonal unit) | 0.99 (0.97–1.01) | 0.50 | 0.99 (0.96– 1.02) | 0.64 | ||
| Model stratified by cancer status (unadjusted odds ratios for continuous BMI, per additional unit) | ||||||
| Subtype stratum | ||||||
| HR+/HER2− | 378 | 64 (16.9) | 1.01 (0.96–1.05) | 0.81 | ||
| HR+/HER2+ | 155 | 57 (36.8) | 0.97 (0.91–1.03) | 0.32 | ||
| HR−/HER2+ | 88 | 55 (62.5) | 0.93 (0.86–1.00) | 0.06 | ||
| HR−/HER2− | 356 | 139 (39.0) | 1.00 (0.97–1.04) | 0.99 | ||
*
Adjusted for age at screening, hormonal cancer subtype, race, stage, and menopausal status