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[Preprint]. 2023 Jun 16:rs.3.rs-3026818. [Version 1] doi: 10.21203/rs.3.rs-3026818/v1

Fig. 1. Cryo-EM structure of Retriever reveals a unique assembly mechanism.

Fig. 1.

(A) Cryo-EM map (EMD: 40886; PDB: 8SYO) and schematic of the Retriever complex. Dotted lines represent the putative flexible linker sequence in VPS35L not observed in the map. (B) Structural comparison between Retriever (top) and Retromer (bottom, PDB: 7U6F). Secondary structural elements of the remotely homologous proteins, including VPS35L vs. VPS35 and VPS26C vs. VPS26A, are labeled. The “belt” sequence unique to VPS35L is traced by yellow dotted lines.