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. 2023 Jun 16;13:1105474. doi: 10.3389/fonc.2023.1105474

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Copyright © 2023 Wang, Liu, Zhang, Zhang, Ran, Ma, Yang, Wang, He, Zhao, Wang, Zhang, Dong and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mutational landscape and KEGG pathways. (A) Mutational landscape of primary breast tumors from four of seven patients with BM and five of 10 patients without BM. Displayed are mutations, indels, and amplification likely to be pathogenic, summarized by gene for each patient. Bottom bar refers to group (BM and non-BM). Right, variant classification of the alterations within each gene. (B) KEGG pathways of all samples from patients with BM (including 17 plasma samples and four tissue samples of primary breast tumors). The y-axis represents KEGG-enriched terms. The x-axis represents the rich factor. The size of the dot represents the number of genes under a specific term. The color of the dots represents the adjusted p-value. BM, brain metastasis; KEGG, Kyoto Encyclopedia of Genes and Genomes.