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. 2023 Jun 16;13:1105474. doi: 10.3389/fonc.2023.1105474

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Copyright © 2023 Wang, Liu, Zhang, Zhang, Ran, Ma, Yang, Wang, He, Zhao, Wang, Zhang, Dong and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Discrepancies of TMB, number of clusters, and consistency of mutated profiles of peripheral blood and primary lesion in patients with brain metastasis and without brain metastasis. (A) Clonal cluster number from seven patients with BM and nine of 10 patients without BM; p- values by t-test. (B) TMB from seven patients with BM and 10 patients without BM; p -values by Mann–Whitney U-test. (C) Discrepancy of consistency of mutated profiles of peripheral blood and primary lesion between patients with BM and without BM; p -values by Mann–Whitney U-test. BM, brain metastasis; TMB, tumor mutational burden.