TABLE 5.

Major MeSH terms/MeSH subheadings from the included publications on transdermal drug delivery (n = 1,542).

Rank	Major MeSH terms/MeSH subheadings	Frequency	Proportion of frequency (%)	Cumulative percentage (%)
1	Drug Delivery Systems	332	5.9723	5.9723
2	Skin/metabolism	159	2.8602	8.8325
3	Pharmaceutical Preparations/administration and dosage	151	2.7163	11.5488
4	Skin Absorption	93	1.673	13.2218
5	Drug Carriers/chemistry	75	1.3492	14.571
6	Nanoparticles	59	1.0613	15.6323
7	Drug Delivery Systems/instrumentation	59	1.0613	16.6936
8	Vaccines/administration and dosage	54	0.9714	17.665
9	Nanoparticles/chemistry	51	0.9174	18.5824
10	Skin Diseases/drug therapy	39	0.7016	19.284
11	Transdermal Patch	39	0.7016	19.9856
12	Dermatologic Agents/administration and dosage	36	0.6476	20.6332
13	Skin Absorption/drug effects	35	0.6296	21.2628
14	Parkinson Disease/drug therapy	33	0.5936	21.8564
15	Insulin/administration and dosage	31	0.5577	22.4141
16	Skin Absorption/physiology	30	0.5397	22.9538
17	Polymers/chemistry	30	0.5397	23.4935
18	Microinjections/instrumentation	28	0.5037	23.9972
19	Analgesics, Opioid/administration and dosage	26	0.4677	24.4649
20	Pharmaceutical Preparations	26	0.4677	24.9326
21	Lipids/chemistry	26	0.4677	25.4003
22	Nanoparticles/administration and dosage	26	0.4677	25.868
23	Alzheimer Disease/drug therapy	22	0.3958	26.2638
24	Drug Design	20	0.3598	26.6236
25	Pharmaceutical Preparations/metabolism	20	0.3598	26.9834
26	Contraceptive Agents, Female/administration and dosage	17	0.3058	27.2892
27	Drug Compounding/methods	13	0.2339	27.5231
28	Nanotechnology/methods	12	0.2159	27.739