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. 2023 Jul 3;133(13):e166070. doi: 10.1172/JCI166070

Figure 5. scRNA-Seq of murine DLBCL-FRCs reveals altered chemokine and antigen-presentation gene pathways.

Figure 5

(A) UMAP of scRNA-Seq data generated from FACS-sorted LN stromal cells for WT-FRCs (1,408 cells) and IμHABcl6-FRCs (1,422 cells). Seven clusters (c0–c6) identified with FRC-reclustered analysis. (B) Heatmap showing the top 20 genes and average expression levels in each cluster and their assigned identity (FDR < 0.001 and highest log-fold changes). (C) Distribution of FRC clusters in IμHABcl6 versus WT. Upper panels, UMAP of FRC clusters across the WT (left) and IμHABcl6 (right) samples. Lower panel, histogram showing frequency of FRC clusters in WT and IμHABcl6. (D and E) Violin plots of Ccl21 and Cxcl9 (D)and B2m and Cd74 (E) expression in IμHABcl6-FRC versus WT-FRC clusters.