Table 2.
The association between FKBP5 SNPs and different psychiatric diseases.
| Psychiatric disorder | FKBP5 SNP | Allele | Type of association | P-value | References | Number of participants |
|---|---|---|---|---|---|---|
| Maladaptive emotional behavior | rs1360780 | T | Increased risk of psychiatric disorders | N/A | Halldorsdottir et al. (105) | 114 homozygous CATT 530 heterozygous CATT 701 homozygous non-carrier |
| rs9470080 | T | N/A | ||||
| rs9296158 | C | N/A | ||||
| rs3800373 | A | N/A | ||||
| Neuroticism | rs9470080 | T | Increased risk | 0.006 | Mihaljevic et al. (101) | 52 cases vs. 51 controls |
| Mood disorders | rs4713916 | A | Increased treatment response to drugs | 0.01 | Zou et al. (106) | Meta-analysis of three studies with 1,101 subjects |
| Bipolar disorder | rs4713902 | T | Increased risk | 0.0001 | Willour et al. (30) | 1,188 subjects |
| rs7757037 | A | Increased risk | 0.001 | |||
| rs3800373 | G | Increased risk | 0.0046 | Calabrò et al. (107) | 131 subjects vs. 65 controls | |
| Unipolar depression | rs1360780 | T | Increased anti-depressant treatment response | 0.01 | Stamm et al. (108) | 127 cases vs. 171 controls |
| rs3800373 | A, C | Increased risk | 0.014 | Zobel et al. (134) | 268 cases vs. 284 controls | |
| Depression | rs4713916 | N/A | Increased risk of depression | N/A | Hernández-Díaz et al. (109) | A meta-analysis of 4 studies with 2,614 participants |
| rs3800373 | C | Increased risk of depression | N/A | |||
| rs3800373 | C | More frequent in depressed subjects | N/A | Wang et al. (110) | A meta-analysis of 14 studies with 15,109 participants | |
| rs1360780 | T | Increased risk under childhood adversity | < 0.0001 | |||
| rs9470080 | N/A | Robust associations | N/A | |||
| rs3800373 | N/A | Robust associations | N/A | |||
| rs9470080 | G | Increased risk of depressive symptoms | 0.037 | Velders et al. (111) | A meta-analysis of 4 studies with 3,550 participants | |
| rs1360780 | T | Increased recurrences of depressive episodes | 0.019 | Shibuya et al. (36) | 449 male vs. 377 female | |
| MDD | rs4713916 | A, G | Increased risk | 0.038 | Szczepankiewicz et al. (112) | 218 cases vs. 742 controls |
| rs9470080 | T | Increased risk | 0.007 | |||
| rs1360780 | T | Increased risk | 0.011 | |||
| rs9296158 | A | Increased risk | 0.03 | |||
| rs9394309 | A | Increased risk | 0.018 | |||
| rs3800373 | C | Increased risk | 0.002 | Rao et al. (113) | 12,491 cases vs. 14,091 controls | |
| rs3800373 | C | Increased risk | 0.037 | Tatro et al. (114) | 48 cases vs. 12 controls | |
| rs1360780 | T | Increased risk | 0.05 | Mikolas et al. (115) | 85 cases vs. 67 controls | |
| rs1360780 | T | Lower in MDD patients | 0.04 | Arlt et al. (116) | 44 cases vs. 202 controls | |
| Combined PTSD-MDD | rs9470080 | T | Increased risk after low-level trauma exposure | 0.003 | Li et al. (117) | 586 low-level trauma vs. 554 high-level trauma cases |
| PTSD | rs1360780 | T | Decreased risk | 0.037 | Kang et al. (118) | 123 cases vs. 116 controls |
| rs9296158 | A | Increased risk | 0.01 | Hawn et al. (119) | A meta-analysis of 9 studies with 8,511 participants | |
| rs3800373 | A | Increased risk | N/A | Zhang et al. (120) | 772 women vs. 360 men | |
| rs9470080 | T | Increased risk | 0.05 | |||
| rs9470080 | C | Increased risk | 0.001 | Zhang et al. (121) | 341 cases vs. 3514 control | |
| rs3800373 | A | Increased risk | 0.004 | |||
| rs3800373 | C | Interacted with early-life stress to predict higher risks for PTSD | < 0.001 | Wang et al. (110) | A meta-analysis of 14 studies with 15,109 participants | |
| rs1360780 | T | < 0.001 | ||||
| rs9470080 | T | < 0.001 | ||||
| Chronic PTSD | rs1360780 | T | Increased risk | 0.037 | Kang et al. (118) | 123 cases vs. 116 controls |
| Anxiety disorders | rs1360780 | T | Increased risk | < 0.001 | Minelli et al. (122) | 657 cases vs. 462 controls |
| rs9470080 | T | Increased risk | 0.015 | Bryushkova et al. (123) | 234 cases vs. 233 controls | |
| rs4713916 | A | Increased risk in women | < 0.001 | Isaksson et al. (124) | 2,029 males vs. 2,348 females | |
| Impulsive behavior | rs1360780 | T | Reduce impulsivity in intertemporal choice | 0.047 | Kawamura et al. (125) | 91 healthy Japanese people |
| ADHD | rs9470080 | C | Increased risk | 0.022 | Isaksson et al. (126) | 81 children with ADHD vs. 88 controls |
| rs7748266 | C | Increased risk | 0.019 | |||
| rs9394309 | A | Increased risk | 0.013 | |||
| Schizophrenia | rs9470080 | C | Increased risk | 0.044 | Mihaljevic et al. (101) | 52 cases vs. 51 controls |
| rs9296158 | A | Increased risk | 0.03 | |||
| rs3800373 | G | Increased risk | 0.041 | |||
| Suicide | rs1360780 | T | Increased risk of suicide | N/A | Hernández-Díaz et al. (109) | Meta-analysis of 3 studies with 751 cases and 703 controls |
| rs4713902 | G | Increased risk | 0.023 | Roy et al. (31) | 198 cases vs. 682 controls | |
| rs3800373 | C | High-induction allele | 0.007 | Fudalej et al. (127) | 563 cases vs. 475 controls | |
| rs1360780 | T | Increased frequency of suicide | 0.026 | |||
| Drug abuse | rs1360780 | T | Increased risk | 0.04 | Levran et al. (128) | 852 cases vs. 238 controls |
| rs3800373 | A | Increased risk | 0.03 | |||
| rs3800373 | A, C | Increased risk of addiction | 0.03 | Levran et al. (129) | 595 subjects vs. 208 controls | |
| rs1360780 | C, T | Increased risk of addiction | 0.04 | |||
| Borderline personality disorder | rs9470079 | A | Increased risk | 0.01 | Martín-Blanco et al. (130) | 481 subjects vs. 442 controls |
| rs4713902 | C | Decreased risk | 0.03 | |||
| rs3798347 | T | More frequent in emotionally neglected cases | 0.03 | |||
| rs10947563 | A | 0.02 | ||||
| Antisocial personality disorder | rs1360780 | T | Increased risk | 0.035 | Suchting et al. (131) | 48 participants before and after giving 20 mg of cortisol |