Table 2.
Univariable and multivariable Cox regression analysis of immunohistochemical, demographic and clinical data in relation to locoregional recurrence
| Characteristic | Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|---|
| Locoregional recurrence/number of patients (%) | HR (95% CI) | p-value | HR (95% CI) | p-value | |
| HIF-1α | |||||
| Low | 9/43 (21) | 1 | 0.043 | 1 | 0.001 |
| High | 7/18 (39) | 2.81 (1.03–7.61) | 7.67 (2.21–26.62) | ||
| CA-IX | |||||
| Low | 13/51 (25) | 1 | 0.710 | ||
| High | 3/10 (30) | 1.27 (0.36–4.46) | |||
| Ki-67 | |||||
| High | 5/11 (45) | 1 | 0.077 | ||
| Low | 11/50 (22) | 0.39 (0.13–1.11) | |||
| Age, years | |||||
| < 65 | 8/24 (33) | 1 | 0.346 | ||
| ≥ 65 | 8/37 (22) | 0.62 (0.23–1.66) | |||
| Sex | |||||
| Female | 3/8 (38) | 1 | 0.490 | ||
| Male | 13/53 (25) | 0.64 (0.18–2.26) | |||
| T-status | |||||
| T3 | 8/38 (21) | 1 | 0.294 | ||
| T4 | 8/23 (35) | 1.69 (0.63–4.51) | |||
| N-status | |||||
| N0 | 7/45 (16) | 1 | < 0.001 | 1 | < 0.001 |
| N+ | 9/16 (56) | 6.39 (2.35–17.36) | 14.07 (4.10–48.34) | ||
Bold value indicates significant p-values (p < 0.05)
HR hazard ratio, 95% CI 95% confidence interval