Table 3.
Univariable and multivariable Cox regression analysis of immunohistochemical, demographic and clinical data in relation to disease-specific mortality
| Characteristic | Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|---|
| Death due to LSCC/number of patients (%) | HR (95% CI) | p-value | HR (95% CI) | p-value | |
| HIF-1α | |||||
| Low | 8/43 (19) | 1 | 0.783 | ||
| High | 3/18 (17) | 0.83 (0.22–3.14) | |||
| CA-IX | |||||
| Low | 8/51 (16) | 1 | 0.324 | ||
| High | 3/10 (30) | 1.95 (0.52–7.37) | |||
| Ki-67 | |||||
| High | 4/11 (36) | 1 | 0.076 | ||
| Low | 7/50 (14) | 0.33 (0.10–1.12) | |||
| Age, years | |||||
| < 65 | 5/24 (21) | 1 | 0.760 | ||
| ≥ 65 | 6/37 (16) | 0.83 (0.25–2.73) | |||
| Sex | |||||
| Female | 4/8 (50) | 1 | 0.021 | 1 | 0.104 |
| Male | 7/53 (13) | 0.23 (0.07–0.80) | 0.35 (0.10–1.24) | ||
| T-status | |||||
| T3 | 6/38 (16) | 1 | 0.659 | ||
| T4 | 5/23 (22) | 1.31 (0.40–4.29) | |||
| N-status | |||||
| N0 | 3/45 (7) | 1 | < 0.001 | 1 | < 0.001 |
| N+ | 8/16 (50) | 11.25 (2.97–42.63) | 9.73 (2.52–37.52) | ||
Bold value indicates significant p-values (p < 0.05)
HR hazard ratio, 95% CI 95% confidence interval