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. 2023 May 13;393(1):133–147. doi: 10.1007/s00441-023-03776-4

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Localization of FILIP1 in adult mouse muscle. (a–b'') Immunolocalization of FLNc and FILIP1 in longitudinal cryosections of adult mouse soleus muscle indicates a localization of both proteins in the Z-disc region of the myofibrils (arrowheads). The boxed area in (a–a'') is shown enlarged in (b–b''). (c–c''') Localization of FLNc, FILIP1 and a Z-disc epitope of titin in a macrolesion and a microlesion (asterisk). FLNc and FILIP1, but not titin, are concentrated in lesions. FLNc shows a more filamentous staining than FILIP1 that shows a more diffuse localization and is only associated with individual filaments (arrows). Arrowheads indicate the position of Z-discs within the macrolesion. Due to the short exposure because of the enhanced signal in the lesions, Z-disc staining of FLNc and FILIP1 is not visible. Bars: 10 m