Table 4.
Top 10 cell‐specific differentially methylated regions determined using tensor composition analysis*
| Region, chr:bp | Model | Cell type | No. CpG | Δ Methylation | P | GREAT annotation | Illumina annotation | ||
|---|---|---|---|---|---|---|---|---|---|
| Gene† | Gene | Feature | CpG island | ||||||
| 1:161008461–61008826 | T0: R–NR | CD8T | 8 | Hyper | 1 × 9.5−18 | TSTD1 (+136) | TSTD1 | TS200 | Island |
| 12:9217389–9217907 | T0: R–NR | Bcell | 10 | Hyper | 1 × 5.8−15 | – | LOC144571 | TS200 | Island |
| 1:202310823–202311278 | T1: R–NR | Neu | 7 | Hyper | 1 × 3.1−14 | UBE2T (+57) | UBE2T | TS200 | Island |
| 17:6899084–6899577 | T1: R–NR | Mono | 11 | Hyper | 1 × 2.0−13 | ALOX12 (–53) | ALOX12 | TS200 | Island |
| 13:36871753–36872346 | R: T1–T0 | NK | 9 | Hypo | 1 × 8.6−13 | – | C13orf38 | TS200 | Island |
| 1:161008461–161008826 | T0: R–NR | CD4T | 8 | Hypo | 1 × 1.8−12 | TSTD1 (+136) | TSTD1 | TS200 | Island |
| 17:6899084–6899577 | T1: R–NR | NK | 11 | Hypo | 1 × 4.9−12 | ALOX12 (–53) | ALOX12 | TS200 | Island |
| 10:77542301–77542585 | T0: R–NR | CD4T | 9 | Hyper | 1 × 1.5−11 | C10orf11 (–76) | C10orf11 | TS200 | OpenSea |
| 6:32063725–32064258 | T1: R–NR | NK | 16 | Hypo | 1 × 5.9−11 | TNXB (–50,087) | TNXB | Body | Island |
| 6:31148331–31148748 | T0: R–NR | CD8T | 15 | Hyper | 1 × 1.2−10 | – | – | – | Island |
*
GREAT = Genomic Regions Enrichment of Annotations Tool; chr = chromosome; Hyper = hypermethylation; Hypo = hypomethylation; NR = nonresponder; R = responder; T0 = baseline visit.
†
Distance from CpG to transcription start site of the nearest upstream and downstream gene annotated using rGREAT software.