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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: Arthritis Rheumatol. 2023 Apr 23;75(7):1120–1131. doi: 10.1002/art.42455

Figure 4. Senescence related genes in DPP4 expressing osteoarthritic chondrocytes.

Figure 4.

Osteoarthritic chondrocytes from 8 patients were sorted by DPP4 surface expression using FACS. A) Gene expression was ordered based on the relative differences between sorted DPP4+ and DPP4− chondrocytes. The relative mean (± SEM) difference in gene expression of DPP4+ minus DPP4− sorted osteoarthritic chondrocytes is shown for 33 senescence-related genes. B) Volcano plot of relative gene expression of DPP4+ vs DPP4− sorted chondrocytes demonstrating in DPP4+ a higher expression of DPP4, PVRL4, IL6, CBX4, BAX, SIRT1, CSNK2A, E2F3, PCNA, RB1, CDK4, BMI1, and STAT3 and lower expression of BCL2 and PARP1. Green: negative relative gene expression, red: positive relative gene expression.