Figure 3. Sensitivity analysis of channel numbers in response to changes in parameter values.

Change in number of channels in the membrane (left panels) and sub-membrane (right panels) states over time in response to a 4-, 2-, 1-, 0.5- or 0.25-fold change in α, β, δ, or ψ rates (top to bottom). The number of channels in the membrane increases for increasing forward rates (α and ψ) or decreasing backward rates (β and δ) and vice versa. Channel levels in the sub-membrane state change parallel to those in the membrane state for changes to ψ and δ, whereas changes to α and β only have a transient effect on sub-membrane state levels.