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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: J Physiol. 2023 Feb 20;601(13):2711–2731. doi: 10.1113/JP283976

Figure 5. Calibration of the effects of pentamidine and dofetilide on Kv11.1 trafficking.

Figure 5.

A, The pentamidine concentration dependence of Kv11.1 membrane levels after 24 hours incubation in experimental data from Asahi et al. (2019) (red bars) and model (black bars). B, The concentration dependence of dofetilide-induced rescue of mature Kv11.1 (155 kDa) levels in the presence of pentamidine (10 μmol/L for 48 hours) after 48 hours of incubation in experimental data (Varkevisser et al., 2013) and model. C, The temporal dynamics of dofetilide (1 μmol/L)-induced rescue of mature Kv11.1 levels after 48-hours pre-treatment with 10 μmol/L pentamidine in experimental data (Varkevisser et al., 2013) and model.