Figure 7. Temperature-dependent regulation of K_v11.1 gating.

A, Calibration of the shift in midpoint of voltage dependence and Q₁₀ values for activation, deactivation, inactivation and recovery of I_Kr in experimental recordings (Zhou et al., 1998; Mauerhofer & Bauer, 2016) and model. B, Combined effects of temperature-dependent changes in midpoint and Q₁₀ on I_Kr at 30, 37, and 40 °C. Inset shows voltage-clamp protocol for steady-state and tail I_Kr. C, Relative tail current amplitudes at 23, 35 and 40 °C normalised to 35 °C obtained with the voltage-clamp protocol from panel B in experimental recordings (Amin et al., 2008) and model.