Table 3.
Adapted IKr Markov model parameters from Clancy & Rudy (2001) and calibrated parameters for the effects of temperature on trafficking.
| Baseline MM parameters | Temperature-dependent trafficking regulation | ||
|---|---|---|---|
| Parameter | Value | Parameter | Value |
| p1 | 1.31E-2 | a | 1.2975 |
| p2 | 1.48 | b | 42.2 |
| p3 | 3.3E-3 | c | 1.7 |
| p4 | −5.77E-1 | s | 10 |
| p5 | 2.17 | d | 0.18 |
| p6 | 1.08 | Q 10Activation | 5.64528884 |
| p7 | 3.02E-2 | Q 10Deactivation | 1.19795417 |
| p8 | 2.9E-3 | Q 10Inactivation | 3.41629472 |
| p9 | −9.78E-1 | Q 10Recovery | 2.93346223 |
| p10 | 5.45E-1 | V 1/2Activation/Deactivation | 1.21461546 |
| p11 | −8.17E-1 | V 1/2Inactivation/Recovery | 1.11308848 |
| p12 | 4.5 | ||
| p13 | 8.2E-1 | ||
| p14 | 5.04E-1 | ||
| p15 | 1 | ||
| FRT | 0.037435883507802616 | ||