Table 1.
Demographics and clinical characteristics of healthy subjects and low-teens NTG.
| Healthy group (N = 32) | Low-teens NTG (N = 35) | P-value | |
|---|---|---|---|
| Age (years) | 59.6 ± 13.5 | 58.7 ± 14.2 | 0.655* |
| Sex (Male : Female) | 15 : 17 | 15 : 19 | 0.266† |
| Body-mass index (Kg/m2) | 23.97 ± 2.51 | 23.63 ± 3.07 | 0.836* |
| Diabetes mellitus, n (%) | 6 (18.8) | 7 (20.0) | 0.878† |
| Hypertension, n (%) | 9 (28.1) | 11 (31.4) | 0.945† |
| No. of antihypertensive medications, n | |||
| No medication | 0 | 1 | 0.534† |
| 1 medication | 3 | 4 | |
| ≥ 2 medications | 6 | 6 | |
| Antihypertensive medication type | |||
| ACEIs | 4 | 3 | 0.224† |
| Angiotensin II receptor blocker | 2 | 2 | |
| CCBs | 5 | 5 | |
| Diuretics | 2 | 3 | |
| BRBs | 4 | 5 | |
| Spherical equivalent (Diopters) | -1.05 ± 2.32 | -1.75 ± 3.07 | 0.193* |
| Axial length (mm) | 23.96 ± 1.18 | 24.03 ± 1.23 | 0.597* |
| Central corneal thickness (µm) | 534.46 ± 26.76 | 540.14 ± 43.53 | 0.658* |
| Baseline IOP (mmHg) | 14.2 ± 2.06 | 13.39 ± 1.00 | 0.469* |
| Baseline vertical cup-to-disc ratio | 0.41 ± 0.14 | 0.64 ± 0.21 | < 0.001* |
| Mean cpRNFL thickness (µm) | 101.91 ± 11.47 | 78.57 ± 18.52 | < 0.001* |
| Mean deviation (dB) | 0.22 ± 5.14 | -8.94 ± 8.47 | < 0.001* |
| Glaucoma severity, n (%) | Mild:14 (40) | ||
| Moderate: 14 (40) | |||
| Advanced: 7 (20) | |||
| Severe: 0 (0) | |||
Values are presented as the mean ± standard deviation or number (%).
*Student t-test, † Chi-square test.
ACEI = angiotensin-converting enzyme inhibitor; BRB = beta receptor blocker; CCB = calcium channel blocker; cpRNFL = circumpapillary retinal nerve fiber layer.